SOLVENT-FREE PREPARATION AND ANTIMICROBIAL STUDIES OF METAL (II) COMPLEXES DERIVED FROM CLOXACILLIN

The authors use an environmental friendly, solvent-free method to prepare metal (II) complexes of cloxacillin and determine the activity complexes. are more active against bacteria isolates than free cloxacillin. spectral studies showed (ligand) as monobasic bidentate material that form a complex with ion through carbonyl amide carboxylate groups carboxylic acid, microanalysis results prove ligand ratio is 2:1. researchers recommend drugs in manufacture pharmaceutical ingredients avoid excessive solvents cause global problems.